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Kuo, Jean-Cheng
Kuo, Jean-Cheng
  • Assistant professor
  • Education: PhD. Institute of Molecular Medicine, National Taiwan University, Taiwan
  • Office: R515, 5F, Tradition Medicine Building
  • Phone: 886-2-2826-7120
  • Email 這個 E-mail 地址已經被防止灌水惡意程式保護,您需要啟用 Java Script 才能觀看
  • Personal web site
  • Research field--cell adhesion, dynamic regulation of cytoskeleton
    Cells sense the environment through their adhesive organelles, focal adhesions (FAs), which are able to transduce appropriate biochemical signals to control numerous critical cellular events, including cell migration, proliferation, differentiation or death. FAs are macromolecular complex that start to form when the central components, integrin receptors, are activated by engagement with the extracellular matrix (ECM), and recruit a series of FA-associated proteins to connect with actin cytoskeleton. The protein composition in FAs can be modulated by physical or biochemical stimuli. My research scope has covered two areas:
    1. Using proteomic approach to globally demonstrate how protein composition in FAs is modulated by physical or biochemical stimuli.
    2. Using microscope and biochemical technologies to demonstrate the molecular mechanism of how FA-associated proteins regulate cellular events, including cell migration, proliferation, differentiation or death.
    • Kuo JC, Han X, Yates JR, Waterman CM. Isolation of focal adhesion proteins for biochemical and proteomic analysis. Method Mol. Biology (Integrin and Cell Adhesion Molecules). 757:297-323. 2012.

    • Valdes JL, Tang J, Mcdermott MI, Kuo JC, Zimmerman SP, Wincovitch SM, Waterman CM, Milgram SL, Playford MP. Sorting Nexin 27 mediates PDZ-directed targeting of a #-Pix-Git complex to focal adhesions. J. Biol. Chem. 2011. (in press).

    • Kuo JC, Han X, Hsiao CT, Yates JR, Waterman CM. Analysis of the myosinII-responsive focal adhesion proteome reveals a role for #-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13(4):383-93. 2011.

    • * This paper was selected to be the main Nature Cell Biology April cover, and was the subject of the news and views in Nature Cell Biology (Joan S. Brugge, 13: 344, 2011) and a research highlight in Nature Reviews Molecular Cell Biology (Katrin Legg, 12:278, 2011).

    • Wang WJ, Kuo JC, Ku W, Lee YR, Lin FC, Chang YL, Lin YM, Chen CH, Huang YP, Chiang MJ, Yeh SW, Wu PR, Shen CH, Wu CT, and Chen RH. The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR. Mol. Cell. 27(5):701-16. 2007.

    • Kuo JC, Wang WJ, Yao CC, Wu PR, and Chen RH. The tumor suppressor DAPK inhibits cell motility by blocking integrin-mediated polarity pathway. J Cell Biol. 172(4): 619-31. 2006.

    • Chen RH, Wang WJ, and Kuo JC. The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation. J Biomed Sci. 3: 1-7. 2006.

    • Chen CH, Wang WJ, Kuo JC, Tsai HC, Lin JR, Chang ZF, Chen RH. Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. EMBO J. 24: 294-304. 2005.

    • Kuo JC, Lin JR, Staddon JM, Hosoya H, Chen RH. Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase. J Cell Sci. 116: 4777-4790. 2003.

    • Wang WJ, Kuo JC, Yao CC, Chen RH. DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals. J Cell Biol. 159: 169-79. 2002.

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