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Wei, Yau-Huei
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  • Education: PhD. Biochemistry, State University of New York at Albany
  • Office: R609, 6F, Tradition Medicine Building
  • Phone: 886-2-28267118
  • Email:  joeman@ym.edu.tw This e-mail address is being protected from spambots. You need JavaScript enabled to view it
  • Personal Web Site
  • Research--Biochemical and molecular biological studies on human aging and mitochondrial diseases
  • Molecular and cellular biological studies of human cells harboring mitochondrial DNA mutations associated with mitochondrial diseases and human aging
  • Oxidative stress in human diseases--Molecular and biochemical consequences of oxidative stress elicited by mitochondrial DNA mutations and/or defects in the antioxidant defense system
  • Biochemical and molecular biological studies on mitochondrial roles in diminished fertility of spermatozoa and oocytes
  • Publications-- Over 270 refereed scientific papers have been published in international journals, and more than 30 articles have been published in Symposium Monograph or Special Book Chapters.  A total of 15 invited review articles on mitochondrial DNA mutations in human aging and mitochondrial diseases have recently been published in prestigious international journals.  The Lehninger's Principles of Biochemistry was translated into Chinese for teaching of undergraduate biochemistry (2 volumes).  In addition, a textbook on “Experimental Biochemistry” was written for the teaching of the experiment course of undergraduate biochemistry in Taiwan.
    • Lee, H. C., and Y. H. Wei (2005) Mitochondrial biogenesis and mitochondrial DNA maintenance in mammalian cells under oxidative stress. Int. J. Biochem. Cell Biol. 37:822-834.<pdf>

    • Ma, Y. S., Y. C. Chen, C. Y. Lu, C. Y. Liu, and Y. H. Wei (2005) Up-regulation of matrix metalloproteinase 1 and disruption of mitochondrial network in skin fibroblasts of patients with MERRF syndrome. Ann. N.Y. Acad. Sci. 1042:55-63.

    • Liu, C. S., C. L. Kuo, W. L. Cheng, C. S. Huang, C. F. Lee, and Y. H. Wei (2005) Alteration of the copy number of mitochondrial DNA in leukocytes of patients with hyperlipidemia. Ann. N.Y. Acad. Sci. 1042:70-75.

    • Liu, C. S., W. L. Cheng, Y. Y. Chen, Y. S. Ma, C. Y. Pang, and Y. H. Wei (2005) High prevalence of mitochondrial DNA polymorphism in the COII/tRNALys intergenic 9-bp deletion in Taiwanese patients with MELAS or MERRF syndrome. Ann. N.Y. Acad. Sci. 1042:82-87.

    • Lee, C. F., C. Y. Liu, R. H. Hsieh, and Y. H. Wei (2005) Oxidative stress-induced depolymerization of microtubules and alteration of mitochondrial mass in human cells. Ann. N.Y. Acad. Sci. 1042:246-254.

    • Lee, C. F., C. Y. Liu, S. M. Chen, M. Sikorska, C. Y. Lin, T. L. Chen, and Y. H. Wei (2005) Attenuation of UV-induced apoptosis by coenzyme Q10 in human cells harboring large-scale deletion of mitochondrial DNA. Ann. N.Y. Acad. Sci. 1042:429-438.

    • 20.  Liu, C. S., Y. Y. Chen, W. L. Cheng, C. S. Tsai, C. F. Lee, Y. S. Ma, C. Y. Lin, C. C. Huang, and Y. H. Wei (2006) Alteration of the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies. Acta Neurol. Scand. 113:334-341.

    • Kau, H. C., C. C. Tsai, C. F. Lee,S. C. Kao, W. M. Hsu, J. H. Liu, and Y. H. Wei (2006) Increased oxidative DNA damage, 8-hydroxydeoxyguanosine, in human pterygium. Eye, 20:826-831.

    • Lee, C. F., Y. C. Chen, C. Y. Liu, and Y. H. Wei (2006) Involvement of protein kinase Cd in the alteration of mitochondrial mass in human cells under oxidative stress. Free Radic. Biol. Med., 40:2136-2146.<pdf>

    • YEN MY, WANG AG, WEI YH. (2006) Leber's hereditary optic neuropathy: A multifactorial disease.. Pro. in Retinal and Eye Res.;25:381-396.

    • YANG JH, HSIA TC, KUO HM, LEE CHAO PD, WEI YH, CHUNG JG. (2006) Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis.. Drug Metabolism and Disposition 34:296-304.

    • TSENG LM, YIN PH, CHI CW, HSU CY, WU CW, LEE LM, WEI YH, LEE HC.(2006) Mitochondrial DNA mutations and mitochondrial DNA depletion in breast cancer.. Genes Chromosomes & Cancer 45:629-638.

    • THAJEB P, MA YS, TZEN CY, CHUANG CK, WU TY, CHEN SC, WEI YH. (2006)Oculopharyngeal somatic myopathy in a patient with a novel large-scale 3399 bp deletion and a homoplasmic T5814C transition of the mitochondrial DNA.. Clinical Neurology and Neurosurgery 108:407-410.

    • PENG TI, YU PR, CHEN JY, WU HY, WANG HL, WEI YH, JOU MJ. (2006)Visualizing common deletion of mitochondrial DNA-augmented mitochondrial reactive oxygen species generation and apoptosis upon oxidative stress.. Biochimica et Biophysica Acta- Molecular Basis of Disease 1762:241-255.

    • LAU LI, CHEN SJ, CHENG CY, YEN MY, LEE FL, LIN MW, HSU WM, WEI YH. (2006)Association of the Y402H polymorphism in complement factor H and neovascular age-related macular degeneration in Chinese patients.. Investigative Ophthalmology and Visual Science 47:3242-3246.

    • Hung, W. Y., H. C. Lee, and Y. H. Wei (2006) Alterations of mitochondria in tumors and recent advances in the development of mitochondria-targeting chemotherapy. Chemistry 64: 335-349.

    • Liou, C. W., T. K. Lin, H. H. Weng, C. F. Lee, T. L. Chen, Y. H. Wei, S. D. Chen, Y. C. Chuang, S. W. Weng, and P. W. Wang (2007) A common mitochondrial DNA variant and increased body mass index as associated factors for development of type 2 diabetes: Additive effects of genetic and environmental factors. J. Clin. Endocr. Metab. 92:235-239.

    • Liu, C. Y., C. F. Lee, and Y. H. Wei (2007) Quantitative effect of 4,977 bp deletion of mitochondrial DNA on the susceptibility of human cells to UV-induced apoptosis. Mitochondrion 7:89-95.

    • Shieh, D. B., C. C. Chen, T. S. Shih, H. M. Tai, Y. H. Wei, and H. Y. Chang (2007) Mitochondrial DNA alterations in blood of the humans exposed to N,N-dimethylformamide. Chem.-Biol. Interact. 165:211-219.

    • Lee, H. C., and Y. H. Wei (2007) Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp. Biol. Med. 232:592-606. <pdf>

    • Li, J. Y., R. H. Hsieh, N. J. Peng, P. H. Lai, C. F. Lee, Y. K. Lo, and Y. H. Wei (2007) A follow-up study in a Taiwanese family with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes syndrome. J. Formos. Med. Assoc.106:528-536.

    • Liu, C. S., C. H. Chen, H. C. Chiang, C. L. Kuo, C. S. Huang, W. L. Cheng, Y. H. Wei, and H. W. Chen (2007) B-group vitamins, MTHFR C677T polymorphism and carotid intima-media thickness in clinically healthy subjects. Eur. J. Clin. Nutr. 61:996-1003.

    • Yen, M. Y., C. Y. Cheng, A. G. Wang, and Y. H. Wei (2007) The association of human 8-oxoguanine DNA glycosylase genotype and glutathione S-transferase 1 gene polymorphism with Leber’s hereditary optic neuropathy. Invest. Ophthalmol. Vis. Sci., in press.

    • Kao, S. H., H. T. Chao, H. W. Chen, T. I. S. Hwang, T. L. Liao, and Y. H. Wei (2008) Increase of oxidative stress in human sperm with lower motility. Fertil. Steril., in press.

    • Liu, C. S., W. L. Cheng, S. J. Kuo, J. Y. Li, B. W. Soong, and Y. H. Wei (2007) Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases. J. Neurol. Sci., in press.

    • Tsai, C. C., S. C. Kao, C. Y. Cheng, H. C. Kau, W. M. Hsu, C. F. Lee, and Y. H. Wei (2007) Oxidative stress change by systemic corticosteroids treatment of patients with active Graves' ophthalmopathy. Arch. Ophthalmol., in press.

    • Chen, S. S., W. J. Huang, L. S. Chang, and Y. H. Wei (2007) Attenuation of oxidative stress after varicocelectomy in subfertile patients with varicocele. J. Urol., in press.

    • Sun, M. J., Y. H. Wei, W. L. Cheng, C. L. Kuo, S. Sun, H. D. Tsai, and C. S. Liu (2007) Alteration of the content and 4977 bp deletion of mitochondrial DNA in the uterosacral ligament of patients with pelvic organ prolapse before and after menopause. Intl. Urogynecol. J., submitted for publication.

    • Chen, C. T., Y. R. V. Shih, T. K. Kuo, O. K. Lee, and Y. H. Wei (2008) Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells, 2008 Feb 14; [Epub ahead of print], PMID: 18218821 [PubMed - as supplied by publisher].

    • Liu, C. S., W. L. Cheng, S. J. Kuo, J. Y. Li, B. W. Soong, and Y. H. Wei (2008) Depletion of mitochondrial DNA in leukocytes of patients with poly-Q diseases. J. Neurol. Sci. 264:18-21. [Impact Factor: 2.412]

    • Chen, S. S., W. J. Huang, L. S. Chang, and Y. H. Wei (2008) Attenuation of oxidative stress after varicocelectomy in subfertile patients with varicocele. J. Urol. 179:639-642. [Impact Factor: 3.956]

    • Kao, S. H., H. T. Chao, H. W. Chen, T. I. S. Hwang, T. L. Liao, and Y. H. Wei (2008) Increase of oxidative stress in human sperm with lower motility. Fertil. Steril., in press. [Impact Factor: 3.277]

    • Pang, C. Y., Y. S. Ma, and Y. H. Wei (2008) Mitochondrial DNA mutations, functional decline and turnover of mitochondria in aging. Front. Biosci., in press.

    • Sun, M. J., Y. H. Wei, W. L. Cheng, C. L. Kuo, S. Sun, H. D. Tsai, and C. S. Liu (2008) Alteration of the content and 4977 bp deletion of mitochondrial DNA in the uterosacral ligament of patients with pelvic organ prolapse before and after menopause. Intl. Urogynecol. J., submitted for publication.

    • Weng, S. W., T. K. Lin, C. W. Liou, S. D. Chen, Y. H. Wei, H. C. Lee, I. Y. Chen, C. J. Hsieh, and P. W. Wang (2008) Peripheral blood mitochondrial DNA content and dysregulation of glucose metabolism. Diabet. Med., submitted for publication.

    • Wang, H. W., V. Gukassyan, C. T. Chen, Y. H. Wei, H.W. Guo, J. S. Yu, and F. J. Kao (2008) Differentiation of apoptosis from necrosis by dynamic changes of NADH fluorescence lifetime in live cells. J. Biomed. Opt., in revision.

    • Wang, S. H., Y. L. Shih, W. C. Ko, Y. H. Wei, and C. M. Shih (2008) Cd-induced autophagy is mediated by a calcium signaling pathway. Toxicol. Appl. Pharmacol., submitted for publication.

    • Chen, C. T., Y. R. V. Shih, T. K. Kuo, O. K. Lee, and Y. H. Wei* (2008) Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 26:960-968.

    • Kao, S. H., H. T. Chao, H. W. Chen, T. I. S. Hwang, T. L. Liao, and Y. H. Wei* (2008) Increase of oxidative stress in human sperm with lower motility. Fertil. Steril.89:1183-1190.

    • Pang, C. Y., Y. S. Ma, and Y. H. Wei* (2008) Mitochondrial DNA mutations, functional decline and turnover of mitochondria in aging. Front. Biosci. 13:3661-3675.

    • Lin, C. S., L. S. Wang, C. M. Tsai, and Y.H. Wei* (2008) Low copy number and low oxidative damage of mitochondrial DNA are associated with tumor progression in lung cancer tissues after neoadjuvant chemotherapy. Interact. Cardiovasc. Thorac. Surg. 7:954-958.

    • Wei, Y. H.*, S. B. Wu, Y. S. Ma, and H. C. Lee (2009) Respiratory function decline and DNA mutation in mitochondria, oxidative stress and altered gene expression in human aging. Chang Gung Med. J. 32:113-132.

    • Lee, H. C., and Y. H. Wei* (2009) Mitochondrial DNA instability and metabolic shift in human cancers. Int. J. Mol. Sci. 10:674-701.

    • Tsai, C. C., C. Y. Cheng, C. Y. Liu, S. C. Kao, H. C. Kau, W. M. Hsu, and Y. H. Wei* (2009) Oxidative stress in patients with Graves' ophthalmopathy: Relationship between oxidative DNA damage and clinical evolution. Eye, in press.

    • Liu, C. Y., C. F. Lee, and Y. H. Wei* (2009) The role of ROS-elicited apoptosis in the pathophysiology of mitochondrial diseases and neurodegenerative diseases associated with mtDNA mutations. J. Formos. Med. Assoc., in press.

    • Chang, C. J., P. H. Yin, D. M. Yang, C. H. Wang, W. Y. Hung, C. W. Chi, Y. H. Wei*, and H. C. Lee* (2009) Mitochondrial dysfunction-induced amphiregulin upregulation mediates chemo-resistance and cell migration in human hepatoma HepG2 cells. Cell. Mol. Life Sci., in press.

    • Lin, C. S., L. S. Wang, T. Y. Chou, S. C. Chang, W. H. Hsu, and Y.H. Wei* (2009) The role of mitochondrial DNA alterations in esophageal squamous cell carcinomas. J. Thorac. Cardiovas. Surgery, in press.

    • Sun, M.J., W. L. Cheng, Y. H. Wei, C. L. Kuo, S. Sun, H. D. Tsai, H. M. Lin, and C. S. Liu (2009) Low copy number and high 4977 deletion of mitochondrial DNA in uterosacral ligaments are associated with pelvic organ prolapse progression. Int. Urogynecol. J., in press.

    • Chen, Y. F., C. Y. Wu, C. H. Wang, Y. H. Wei, M. T. Hsu, S. F. Tsai, and T. F. Tsai (2009) Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice. Genes & Development, in press.

     
     
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