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Lin, Ta-Hsien
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  • Education: PhD. Chemistry, University of California, San Diego
  • Office: B-15, Chi-Ten Building, Taipei Veterans General Hospital
  • Phone: 886-2-28712121 ext.2703
  • Emailthlin4@ym.edu.tw This e-mail address is being protected from spambots. You need JavaScript enabled to view it
  • Personal Web Site: http://www.mre.vghtpe.gov.tw/laboratory/Nuclear_Magnetic_Resonance/
  • Research
  • Structural Biology, NMR Spectroscopy
  • Publications
    • Yu-Shan Lin, Hsien-Lu Huang, Wei-Ting Liu, Ta-Hsien Lin* and Hsien-Bin Huang*  Identification of the High Molecular Weight Isoform of Phostensin , 2014, Int. J. Mol. Sci., 15, 1068-1079, doi:10.3390/ijms15011068

     

    • Chen-Yuan Kao, Jun-Kun Lai, Ta-Hsien Lin, Yu-Jiun Lin, Jeng-Shiung Jan*, Steven S.-S. Wang* Examining the inhibitory actions of copolypeptides against amyloidfibrillogenesis of bovine insulin, 2013, Biochemical Engineering Journal, 78, 181-188.

     

    • Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Li-Kang Ho, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin*, Yi-Cheng Chen* Effect of Alanine Replacement of L17 and F19 on the Aggregation and Neurotoxicity of Arctic-Type Aβ40, 2013, PLOS ONE, 8, e61847.

     

    • Deli Irene, Fu-Hsing Sung, Jian-Wen Huang, Ta-Hsien Lin, Yi-chen Chen and Chia-Lin Chyan* Resonance assignments and secondary structure of calmodulin in complex with its target sequence in rat olfactory cyclic nucleotide-gated ion channel, 2013, Biomol. NMR Assign., DOI 10.1007/s12104-013-9461-y.

     

    • Deli Irene, Jian-Wen Huang, Tse-Yu Chung, Feng-Yin Li, Jason T.-C. Tzen, Ta-Hsien Lin and Chia-Lin Chyan* Binding orientation and specificity of calmodulin to rat olfactory cyclic nucleotide-gated ion channel, 2013, J. Biomol. Struct. Dyn., 31, 414-425.

     

    • Tzu-Fan Wang, Ning-Sheng Lai, Kuang-Yung Huang, Hsien-Lu Huang, Ming-Chi Lu, Yu-Shan Lin, Chun-Yu Chen, Su-Qin Liu, Ta-Hsien Lin* and Hsien-Bin Huang* Identification and Characterization of the Actin-Binding Motif of Phostensin, 2012, Int. J. Mol. Sci., 13, 15967-15982.

     

    • Chih-Ching Wang, Hsien-bin Huang, Huey-Jen Tsay, Ming-Shi Shiao, Wen-Jin Winston Wu, Yi-Chen Chen* and Ta-Hsien Lin* Characterization of Aβ40 aggregation mechanism probing by Congo red, 2012, J. Biomol. Struct. Dyn., 30, 160-169.

     

    • Yi-Ru Chen, Hsien-bin Huang, Chi-Jen Lo, Chih-Ching Wang, Chia-Li Su, Hsin-Tzu Liu, Ming-Shi Shiao, Ta-Hsien Lin* and Yi-Chen Chen* Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40, 2011, Biochem. Biophy. Res. Commun., 405, 91-95.

     

    • H. Chou, M.F. Tam, S.-S. Lee, R.-B. Tang, T.-H. Lin, H.-Y. Tai, Y.-S. Chen, H.-D. Shen* Asp159 is a critical core amino acid of an IgE-binding and cross-reactive epitope of a dust mite allergen Der f 7, 2011, Molecular Immunology, 48, 2130-2134.

     

    • C. A. Yang, Y. H. Chen, S. C. Ke, Y. R. Chen, H. B. Huang, T. H. Lin* and Y. C. Chen* Correlation of Copper Interaction, Copper-driven Aggregation and Copper-driven H2O2 Formation with Aβ40 Conformation, 2010, Int J Alzheimers Dis 2011, 607861.

     

    • Chun-Yu Chen, Ning-Sheng Lai, Jaw-Ji Yang, Hsien-lu Huang, Wei-ChuanHung, Chin Li, Ta-Hsien Lin* and Hsien-bin Huang* FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1), 2010, Biochem. Biophy. Res. Commun., 391, 698-702. Impact Factor 2.406.

     

    • Yi-Choang Huang, Yi-Chen Chen, Huey-Jen Tsay, Chia-lin Chyan, Chun-Yu Chen, Hsien-bin Huang* and Ta-Hsien Lin*, The effect of PKA-Phosphorylation on the structure of inhibitor-1 studied by NMR spectroscopy, 2010, J. Biochem., 147, 273-278.

     

    • Yang, C. A., Chen, Y. H., Ke, S. C., Chen, Y. R., Huang, H. B., Lin, T. H.*, and Chen, Y. C.*, Correlation of Copper Interaction, Copper-driven Aggregation and Copper-driven H2O2 Formation with Aβ40 Conformation, (2010) Int J Alzheimers Dis 2011, 607861

     

    • Huang, Y. C., Chen, Y. C., Tsay, H. J., Chyan, C. L., Chen, C. Y., Huang, H. B.*, and Lin, T. H.*, The effect of PKA-Phosphorylation on the structure of inhibitor-1 studied by NMR spectrscopy, (2010) Journal of biochemistry 147, 273-278

     

    • Chen, C. Y., Lai, N. S., Yang, J. J., Huang, H. L., Hung, W. C., Li, C., Lin, T. H.*, and Huang, H. B.*, FLJ23654 encodes a heart protein phosphatase 1-binding protein (Hepp1), (2010) Biochemical and biophysical research communications 391, 698-702

     

    • Lai, N. S., Wang, T. F., Wang, S. L., Chen, C. Y., Yen, J. Y., Huang, H. L., Li, C., Huang, K. Y., Liu, S. Q., Lin, T. H.*, and Huang, H. B.*, Phostensin caps to the pointed end of actin filaments and modulates actin dynamics, (2009) Biochemical and biophysical research communications 387, 676-681

     

    • Liao, M. Q., Tzeng, Y. J., Chang, L. Y., Huang, H. B., Lin, T. H., Chyan, C. L., and Chen, Y. C., The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated A# peptides, (2007) FEBS letters 581, 1161-1165

     

    • Kao, S. C., Chen, C. Y., Wang, S. L., Yang, J. J., Hung, W. C., Chen, Y. C., Lai, N. S., Liu, H. T., Huang, H. L., Chen, H. C., Lin, T. H.*, and Huang, H. B.*, Identification of phostensin, a PP1 F-actin cytoskeleton targeting subunit, (2007) Biochemical and biophysical research communications 356, 594-598

     

    • Huang, H. B.*, Chen, Y. C., Lee, T. T., Huang, Y. C., Liu, H. T., Liu, C. K., Tsay, H. J., and Lin, T. H.*, Structural and Biochemical Characterization of Inhibtor-1alpha, (2007) Proteins 68, 779-788

     

    • Chen, Y. R., Huang, H. B., Chyan, C. L., Shiao, M. S., Lin, T. H.*, and Chen, Y. C.*, The Effect of Abeta Conformation on the Metal Affinity and Aggregation Mechanism Studied by Circular Dichroism Spectroscopy, (2006) Journal of biochemistry 139, 733-740

     

    • Lou, B. S., Lin, T. H., and Lo, C. Z., The interactions of phenytoin and its binding site in DI-S6 segment of Na+ channel voltage-gated peptide by NMR spectroscopy and molecular modeling study , (2005) The journal of peptide research : official journal of the American Peptide Society 66, 27-38

     

    • Lin, T. H., Tsai, P. C., Liu, H. T., Chen, Y. C., Wang, L. H., Hsieh, F. K., and Huang, H. B., Characterization of the Protein Phosphatase 1-binding Motifs of Inhibitor-2 and DARPP-32 by Surface Plasmon Resonance, (2005) Journal of biochemistry 138, 697-700

     

    • Lin, T. H., Huang, H. B., Wei, H. A., Shiao, S. H., and Chen, Y. C.,  The effect of temperature and lipid on the conformational transition of gramicidin A in lipid vesicles, (2005) Biopolymers 78, 179-186

     

    • Ho, Y., Hsiao, J. C., Yang, M. H., Chung, C. S., Peng, Y. C., Lin, T. H., Chang, W., and Tzou, D. L.,  The Oligomeric Structure of Vaccinia Viral Envelope Protein A27L is Essential for Binding to Heparin and Heparan Sulfates on Cell Surfaces: A Structural and Functional Approach Using Site-specific Mutagenesis, (2005) Journal of molecular biology 349, 1060-1071

     

    • Chyan, C. L., Huang, P. C., Lin, T. H., Huang, J. W., Lin, S. S., Huang, H. B., and Chen, Y. C., Purification, crystallization and preliminary crystallographic studies of a Camodulin-OLFp molecule , (2005) Acta crystallographica. Section F, Structural biology and crystallization communications 61, 785-787

     

    • Chou, C. Y., Lin, Y. L., Huang, Y. C., Sheu, S. Y., Lin, T. H., Tsay, H. J., Chang, G. G., and Shiao, M. S., Structural Variation in Human Apolipoprotein E3 and E4: Secondary Structure, Tertiary Structure, and Size Distribution , (2005) Biophysical journal 88, 455-466

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